Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2022
Redaktører
Oddmund HjukseSammendrag
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Redaktører
Erik BøeSammendrag
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Redaktører
Siv Karin Paulsen RyeSammendrag
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Forfattere
Elizabeth Tettey Owusu Fordjour Aidoo Linda Arhin Ritter Atoundem Guimapi Fred Kormla Ablormeti Frank Dampare Richard Ampadu-Ameyaw Jeffet Ekow Cobbah Yayra Afram Frank Kwarteng Ndede YankeySammendrag
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Forfattere
Håvard EikemoSammendrag
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Sammendrag
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Forfattere
Henriette Engen BergSammendrag
A significant challenge in medical diagnostics is the development of simple but efficient tools for the detection/quantification of several biomarkers simultaneously using non-invasive sampling techniques. In this regard, the analysis of proteins (proteomics) is essential for understanding cellular processes and biomarker discovery. However, proteins vary greatly in terms of concentration levels and chemical properties in biological materials. Further, low sample sizes of modern biological models (e.g., patient-derived cell cultures, exosomes, and organoids) remain a big analytical challenge. The present work has focused on the brain cancer glioblastoma, which is in great need of increased knowledge and non-invasive sampling techniques. In addition, human organoids, which could act as a future in vitro model for disease modeling and personalized medicine, have been investigated. We have used high-resolution mass spectrometry for protein identification, exploring a selection of miniaturized liquid chromatography formats (for separation) and sample preparation techniques. By implementing these techniques, we have been able to study exosomes, 2D/3D cell cultures, and organoids, identifying over 6300 proteins in a single run using less than 5 µg of protein. The work has provided important insight into the possibilities and challenges of several novel models. It represents a development toward deeper proteomic profiling focusing on maintaining a high protein yield and time efficiency.
Forfattere
Ercan Yildiz Mehmet Yaman Sezai Ercisli Ahmet Sumbul Osman Sonmez Adem Gunes Mehmet Ramazan Bozhuyuk Darius KviklysSammendrag
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Forfattere
Giorgia CarnovaleSammendrag
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Forfattere
Giorgia CarnovaleSammendrag
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