Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2017
Forfattere
Mihaela-Olivia Dobrica Catalin Lazar Lisa Paruch Hanne Skomedal Hege Særvold Steen Sissel Haugslien Catalin Tucureanu Iuliana Caras Adrian Onu Sonya Ciulean Alexandru Branzan Jihong Liu Clarke Crina Stavaru Norica Branza-NichitaSammendrag
Chronic Hepatitis B Virus (HBV) infection leads to severe liver pathogenesis associated with significant morbidity and mortality. As no curable medication is yet available, vaccination remains the most costeffective approach to limit HBV spreading and control the infection. Although safe and efficient, the standard vaccine based on production of the small (S) envelope protein in yeast fails to elicit an effective immune response in about 10% of vaccinated individuals, which are at risk of infection. One strategy to address this issue is the development of more immunogenic antigens. Here we describe a novel HBV antigen obtained by combining relevant immunogenic determinants of S and large (L) envelope proteins. Our approach was based on the insertion of residues 21-47 of the preS1 domain of the L protein (nomenclature according to genotype D), involved in virus attachment to hepatocytes, within the external antigenic loop of S. The resulting S/preS121-47 chimera was successfully produced in HEK293T and Nicotiana benthamiana plants, as a more economical recombinant protein production platform. Comparative biochemical, functional and electron microscopy analysis indicated assembly of the novel antigen into subviral particles in mammalian and plant cells. Importantly, these particles preserve both S- and preS1-specific epitopes and elicit significantly stronger humoral and cellular immune responses than the S protein, in both expression systems used. Our data promote this antigen as a promising vaccine candidate to overcome poor responsiveness to the conventional, S protein-based, HBV vaccine.
Forfattere
Ólöf Dóra Bartels Jónsdóttir Julia Schregel Snorre Hagen Camilla Tobiassen Siv Aarnes Albert ImslandSammendrag
The potential for genetic contamination of stocks arising from translocation and subsequent release or escape of translocated and/or genetically mixed stocks may be a significant risk to wild populations. In this context, we undertook a population genetic survey of stocks of lumpfish (Cyclopterus lumpus) along the Norwegian coast to establish the existing genetic population structure, which will aid the development of policy of the species’ use as cleaner fish in salmonid aquaculture. This was done by using 14 microsatellite loci and 287 specimens collected at five fishing grounds, covering most of the Norwegian coastline from south to north, with additional 18 samples of first-generation reared fish from a fish farm outside Tromsø (North Norway). Overall, there was no indication of significant spatial genetic structuring or of positive correlation between geographic and genetic distance among the wild lumpfish samples. These results suggest that, should translocated individuals escape from aquaculture in Norway, this will probably have little to no impact on the genetic composition of the local fish population.
Forfattere
Jostein FrydenlundSammendrag
Arealstatistikk for Nord-Trøndelag fylke basert på arealressurskartet AR5 og søknader om produksjonstilskudd. Dokumentet inneholder også informasjon om strukturendring i landbruket og nedbygd jordbruksareal.
Forfattere
Jostein FrydenlundSammendrag
Arealstatistikk for Sør-Trøndelag fylke basert på arealressurskartet AR5 og søknader om produksjonstilskudd. Dokumentet inneholder også informasjon om strukturendring i landbruket og nedbygd jordbruksareal.
Forfattere
Xiaobo Zhu Mingguo Ma Hong Yang Wei GeSammendrag
Det er ikke registrert sammendrag
Forfattere
Jostein FrydenlundSammendrag
Arealstatistikk for Møre og Romsddal fylke basert på arealressurskartet AR5 og søknader om produksjonstilskudd. Dokumentet inneholder også informasjon om strukturendring i landbruket og nedbygd jordbruksareal.
Sammendrag
Det er ikke registrert sammendrag
Forfattere
Anne Kjersti Bakken Kristin Daugstad Astrid Johansen Anne-Grete Roer Hjelkrem Gustav Fystro Anders Hammer Strømman Audun KorsæthSammendrag
This is the authors' accepted and refereed manuscript to the article. Locked until 18 September 2019 due to copyright restrictions.
Sammendrag
Det er ikke registrert sammendrag
Forfattere
Callum Aidan Stephen Hill Greeley BeckSammendrag
This paper discusses the applicability of the Flory–Huggins and Vrentas sorption models for studying the sorption behaviour of wood. This theory was originally developed to explain the sorption behaviour of glassy polymers and was further extended to account for hysteresis effects. The model also has the advantage that, in principle, it does not require adjustable parameters for fitting and can be calculated independently of the sorption isotherm data. It was tested against some sorption isotherms and satisfactory fits to the data were obtained for both the absorption and desorption data. The values of the parameters required for satisfactory fitting were realistic, except for the magnitude of the glass transition temperature of water. As far as the authors are aware, this is the first reported study of the use of the Vrentas model to explain sorption and hysteresis in wood.