Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2023
Sammendrag
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Forfattere
Geir Orderud Petr Porcal Bjørnar Eikebrokk Jiří Sláma Rolf David Vogt Josef Hejzlar Ståle HaalandSammendrag
Several actors have an impact on the quality of drinking water, but ultimately drinking water treatment plants (DWTPs) play a decisive role in ensuring that water quality complies with public regulations. Several developing technologies are combined in water treatment processes. In this paper, we are analysing the technological development of DWTPs in the South Bohemian region of the Czech Republic. The empirical basis is five DWTPs of varying size, and data are gathered through semi-structured interviews with relevant staff inside and outside of the five DWTPs. This study identifies the interplay of factors driving technological development: public regulations, the economic capacity of local DWTP owners together with subsidies from the European Union and national authorities, political priorities by local authorities, and the knowledge network. The paper addressess learning–knowledge–change processes of DWTPs, thereby contributing to our understanding of developing competence in producing drinking water. Generally, large DWTPs are front-runners in introducing new technologies while the smaller ones are lagging. Still, private companies operating small plants on behalf of municipal owners ensure that those DWTPs are part of a wider knowledge network, aiding to introduce a necessary and cost-effective upgrade to treatment steps.
Sammendrag
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Forfattere
Trygve S. AamlidSammendrag
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Forfattere
Sebastian EiterSammendrag
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Forfattere
Geir-Harald StrandSammendrag
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Forfattere
Ana-Maria Madalina Pantazica Andre van Eerde Mihaela-Olivia Dobrica Iuliana Caras Irina Ionescu Adriana Costache Catalin Tucureanu Hege Særvold Steen Catalin Lazar Inger Heldal Sissel Haugslien Adrian Onu Crina Stavaru Norica Branza-Nichita Jihong Liu ClarkeSammendrag
The recent SARS-CoV-2 pandemic has taught the world a costly lesson about the devastating consequences of viral disease outbreaks but also, the remarkable impact of vaccination in limiting life and economic losses. Vaccination against human Hepatitis B Virus (HBV), a major human pathogen affecting 290 million people worldwide, remains a key action towards viral hepatitis elimination by 2030. To meet this goal, the development of improved HBV antigens is critical to overcome non-responsiveness to standard vaccines based on the yeast-produced, small (S) envelope protein. We have recently shown that combining relevant immunogenic determinants of S and large (L) HBV proteins in chimeric antigens markedly enhances the anti-HBV immune response. However, the demand for cost-efficient, high-quality antigens remains challenging. This issue could be addressed by using plants as versatile and rapidly scalable protein production platforms. Moreover, the recent generation of plants lacking β-1,2-xylosyltransferase and α-1,3-fucosyltransferase activities (FX-KO), by CRISPR/Cas9 genome editing, enables production of proteins with “humanized” N-glycosylation. In this study, we investigated the impact of plant N-glycosylation on the immunogenic properties of a chimeric HBV S/L vaccine candidate produced in wild-type and FX-KO Nicotiana benthamiana. Prevention of β-1,2-xylose and α-1,3-fucose attachment to the HBV antigen significantly increased the immune response in mice, as compared with the wild-type plant-produced counterpart. Notably, the antibodies triggered by the FX-KO-made antigen neutralized more efficiently both wild-type HBV and a clinically relevant vaccine escape mutant. Our study validates in premiere the glyco-engineered Nicotiana benthamiana as a substantially improved host for plant production of glycoprotein vaccines.
Sammendrag
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Forfattere
Ruben Erik Roos Johan Asplund Tone Birkemoe Aud Helen Halbritter Rechsteiner Siri Lie Olsen Linn Vassvik Kristel van Zuijlen Kari KlanderudSammendrag
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Forfattere
Åsmund Mikalsen KvifteSammendrag
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