Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2021
Sammendrag
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Forfattere
Anne Kjersti BakkenSammendrag
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Forfattere
Fatima Heinicke Xiangfu Zhong Siri Tennebø Flåm Johannes Breidenbach Magnus Leithaug Marthe Thoresen Mæhlen Siri Lillegraven Anna-Birgitte Aga Ellen Sauar Norli Maria Dahl Mjaavatten Espen Andre Haavardsholm Manuela Zucknick Simon Rayner Benedicte Alexandra LieSammendrag
Rheumatoid arthritis (RA) is a complex disease with a wide range of underlying susceptibility factors. Recently, dysregulation of microRNAs (miRNAs) in RA have been reported in several immune cell types from blood. However, B cells have not been studied in detail yet. Given the autoimmune nature of RA with the presence of autoantibodies, CD19+ B cells are a key cell type in RA pathogenesis and alterations in CD19+ B cell subpopulations have been observed in patient blood. Therefore, we aimed to reveal the global miRNA repertoire and to analyze miRNA expression profile differences in homogenous RA patient phenotypes in blood-derived CD19+ B cells. Small RNA sequencing was performed on CD19+ B cells of newly diagnosed untreated RA patients (n=10), successfully methotrexate (MTX) treated RA patients in remission (MTX treated RA patients, n=18) and healthy controls (n=9). The majority of miRNAs was detected across all phenotypes. However, significant expression differences between MTX treated RA patients and controls were observed for 27 miRNAs, while no significant differences were seen between the newly diagnosed patients and controls. Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR-223-3p, miR-486-3p and miR-23a-3p. MiRNA target enrichment analysis, using the differentially expressed miRNAs and miRNA-target interactions from miRTarBase as input, revealed enriched target genes known to play important roles in B cell activation, differentiation and B cell receptor signaling, such as STAT3, PRDM1 and PTEN. Interestingly, many of those genes showed a high degree of correlated expression in CD19+ B cells in contrast to other immune cell types. Our results suggest important regulatory functions of miRNAs in blood-derived CD19+ B cells of MTX treated RA patients and motivate for future studies investigating the interactive mechanisms between miRNA and gene targets, as well as the possible predictive power of miRNAs for RA treatment response.
Forfattere
Selamawit Araya Kidane Beira H. Meressa Solveig Haukeland Trine Hvoslef-Eide Danny L. CoyneSammendrag
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Forfattere
Hannah Wenng Robert Barneveld Marianne Bechmann Hannu Marttila Tore Krogstad Eva SkarbøvikSammendrag
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Forfattere
Anna Avetisyan M. Hokhanyan Kristina Herdt leidulf Lund Anne Linn Hykkerud Laura Jaakola Inger MartinussenSammendrag
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Sammendrag
Agroforestry can be defined as sustainable and multifunctional land-use systems where trees are managed together with agricultural crops or livestock on the same piece of land. This definition fits with how the outfield has been managed in generations in Norway. The Norwegian outfields are a multifunctional land-use system. In the northern periphery area, agroforestry has a long history with woodland grazing, reindeer husbandry and gathering of different non-wood forest resources as herbs, mushrooms, and berries. Traditional agroforestry has gradually disappeared during the 20th century with the intensification of agriculture and forestry. Currently agroforestry systems are gaining new interest, not only from farmers but also from politicians, as this practice can possibly contribute to a more sustainable way of agricultural production. In the northern periphery area, the benefits of agroforestry practices can be manifold not only promoting traditional practices, but also novel systems with the use of new technology. In addition, agroforestry has environmental benefits as a method for conservation and enhancement of biodiversity, improved nutrient cycling, and water quality. Soil humus layer will also increase with several agroforestry systems leading to carbon sequestration. The Norwegian population of 5.3 mill populate an area of 323805 km2. The mainland of Norway is 323805 km2 while Svalbard and Jan Mayen represent 61022 and 377 km2, respectively. Number of persons per km2 are 14, however, as much as 82% of the Norwegian population inhabits cities/densely populated areas. These figures tell us that Norway have a large outfield with forests and mountains. The biggest owner of Norwegian outfield1 is the Norwegian state by the Ministry of Agriculture and Food. The state-owned enterprise Statskog SF is set to administer the property, that alone consist of about 23% of the total outfield-area of Norway. Almost 80% of the state-owned property is above the treeline and covers mountains and alpine grassland who are valuable grazing resources for reindeer herders and local farmers. Most of the forests are also used as grazing areas for local farmers and reindeer herders. The state-owned property in the southern Norway are managed as commons, where locals have rights in commons, typically this is right to graze, hunt and fish on the state ground. In the northern part of Norway, the grazing-rights are defined as user-rights and technically not rights in commons while the right to hunt, fish and gathering of berries and herbs etc. is an “all-mans-right”.
Sammendrag
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Sammendrag
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Sammendrag
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