Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2021
Forfattere
Michel VerheulSammendrag
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Forfattere
Dmitry KechasovSammendrag
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Forfattere
Michel VerheulSammendrag
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Forfattere
Michel VerheulSammendrag
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Sammendrag
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Forfattere
Berit Marie Blomstrand Heidi L Enemark Øivind Øines Håvard Steinshamn Inga Marie Aasen Karl-christian Mahnert Kristin Sørheim Spiridoula Athanasiadou Stig Milan Thamsborg Ian WoolseySammendrag
The widespread apicomplexan parasite Cryptosporidium parvum is responsible for severe gastrointestinal disease in humans and animals. The treatment options are limited, and the efficacy of available drugs is low. Bark contains condensed tannins (CT), which are bioactive compounds previously shown to inhibit parasite development. Here, we examined the anti-cryptosporidial properties of bark extract of Scots pine (Pinus sylvestris) against C. parvum by means of an in vitro growth inhibition test. We hypothesized that bark extracts would have dose-dependent inhibitory effects on the development of C. parvum in cell culture. Bark extracts from Scots pine extracted with acetone, methanol, and water as solvents, were investigated using human colorectal adenocarcinoma cells infected with C. parvum. Oocysts were inoculated onto the cell monolayer and bark extract was added at 7 different concentrations. Parasite growth inhibition was quantified by qPCR. The acetone and methanol extracts demonstrated a sigmoid dose-dependent inhibition of C. parvum. The IC50 values were 244.6 and 279.1 µg dry matter extract/mL, and 25.4 and 24.1 µg CT/mL, for acetone and methanol extracts, respectively. The IC50 for both extracts were similar, both with regards to the dry matter concentration of each extract and to CT concentrations. Given the limited treatment options available for Cryptosporidium spp., the evidence generated in our study encourages further investigation into the in vitro and in vivo effects of pine bark extracts against C. parvum.
Forfattere
Karl Thunes Geir Einar Ellefsen Søli Csaba Thuroczy Arne Fjellberg Stefan Olberg Steffen Roth Carl-C. Coulianos R. Henry L. Disney Josef Stary G. (Bert) Vierbergen Terje Jonassen Johannes Anonby Arne Köhler Frank Menzel Ryszard Szadziewski Elisabeth Stur Wolfgang Adaschkiewitz Kjell M. Olsen Torstein Kvamme Anders Endrestøl Sigitas Podenas Sverre Kobro Lars Ove Hansen Gunnar Mikalsen Kvifte Jean-Paul Haenni Louis BoumansSammendrag
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses /by/4.0/).
Forfattere
Tove Vaaje-KolstadSammendrag
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Forfattere
Tove Vaaje-KolstadSammendrag
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Forfattere
Tove Vaaje-KolstadSammendrag
Det er ikke registrert sammendrag