Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2022
Forfattere
Britt Puidet Romain Mabon Michele Guibert Riinu Kiiker Liina Soonvald Vinh Hong Le Håvard Eikemo Pauline Dewaegeneire Guillaume Saubeau Catherine Chatot Frederique Aurousseau David E. L. Cooke Alison K. Lees Isaac K. Abuley Jens G. Hansen Roselyne Corbiere Melen Leclerc Didier AndrivonSammendrag
Until recently, genotypes of Phytophthora infestans were regionally distributed in Europe, with populations in western Europe being dominated by clonal lineages and those in northern Europe being genetically diverse because of frequent sexual reproduction. However, since 2013 a new clonal lineage (EU_41_A2) has successfully established itself and expanded in the sexually recombining P. infestans populations of northern Europe. The objective of this study was to study phenotypic traits of the new clonal lineage of P. infestans, which may explain its successful establishment and expansion within sexually recombining populations. Fungicide sensitivity, aggressiveness, and virulence profiles of isolates of EU_41_A2 were analyzed and compared with those of the local sexual populations from Denmark, Norway, and Estonia. None of the phenotypic data obtained from the isolates collected from Denmark, Estonia, and Norway independently explained the invasive success of EU_41_A2 within sexual Nordic populations. Therefore, we hypothesize that the expansion of this new genotype could result from a combination of fitness traits and more favorable environmental conditions that have emerged in response to climate change.
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Forfattere
Vibeke LindSammendrag
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Forfattere
Arne SteffenremSammendrag
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Forfattere
Svein Eilertsen Mattias Olsson Andreas Seiler Carolin Berndt Manisha Bhardwaj Aina Iren WinsvoldSammendrag
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Forfattere
Henriette Engen Berg Steven Ray Haakon Wilson Elsa Lundanes Bernd Thiede Einar Osland Vik-MoSammendrag
A significant challenge in medical diagnostics is the development of simple but efficient tools for the detection/quantification of several biomarkers simultaneously using non-invasive sampling techniques. In this regard, the analysis of proteins (proteomics) is essential for understanding cellular processes and biomarker discovery. However, proteins vary greatly in terms of concentration levels and chemical properties in biological materials. Further, low sample sizes of modern biological models (e.g., patient-derived cell cultures, exosomes, and organoids) remain a big analytical challenge. The present work has focused on the brain cancer glioblastoma, which is in great need of increased knowledge and non-invasive sampling techniques. In addition, human organoids, which could act as a future in vitro model for disease modeling and personalized medicine, have been investigated. We have used high-resolution mass spectrometry for protein identification, exploring a selection of miniaturized liquid chromatography formats (for separation) and sample preparation techniques. By implementing these techniques, we have been able to study exosomes, 2D/3D cell cultures, and organoids, identifying over 6300 proteins in a single run using less than 5 µg of protein. The work has provided important insight into the possibilities and challenges of several novel models. It represents a development toward deeper proteomic profiling focusing on maintaining a high protein yield and time efficiency.
Forfattere
El Houssein Chouaib HarikSammendrag
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Forfattere
Kim Viggo Paulsen Weiby Sophie Julie Krizsan Margrete Eknæs Angela Dagmar Schwarm Anne C Whist Ingunn Schei Håvard Steinshamn Peter Lund K.A. Beauchemin Ingjerd DønnemSammendrag
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Forfattere
Brunon Malicki Luis Morgado Jenni Nordén Marit Frederikke Markussen Bjorbækmo Olav Skarpaas O. Janne Kjønaas Bjørn Norden Håvard KauserudSammendrag
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