Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2025
Forfattere
Randi Bolli Ingunn H. Gudmundsdottir Monsås Maren Kolltveit Bakkebø Roman Florinski Kari StuvesethSammendrag
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Heidi Kreibich Murugesu Sivapalan Amir AghaKouchak Nans Addor Hafzullah Aksoy Berit Arheimer Karsten Arnbjerg-Nielsen Cynthia Vail-Castro Christophe Cudennec Mariana Madruga de Brito Giuliano Di Baldassarre David C. Finger Keirnan Fowler Wouter Knoben Tobias Krueger Junguo Liu Elena Macdonald Hilary McMillan E. Mario Mendiondo Alberto Montanari Marc F. Muller Saket Pande Fuqiang Tian Alberto Viglione Yongping Wei Attilio Castellarin Daniel Peter Loucks Taikan Oki María J. Polo Huub Savenije Anne F. Van Loon Ankit Agarwal Camila Alvarez-Garreton Ana Andreu Marlies H. Barendrecht Manuela Brunner Louise Cavalcante Yonca Cavus Serena Ceola Pedro Chaffe Xi Chen Gemma Coxon Zhao Dandan Kamran Davary Moctar Dembélé Benjamin Dewals Tatiana Frolova Animesh K. Gain Alexander Gelfan Mohammad Ghoreishi Thomas Grabs Xiaoxiang Guan David M. Hannah Joerg Helmschrot Britta Höllermann Jean Hounkpè Elizabeth Koebele Megan Konar Frederik Kratzert Sara Lindersson Maria Carmen Llasat Alessia Matanó Maurizio Mazzoleni Alfonso Mejia Pablo Mendoza Bruno Merz Jenia Mukherjee Farzin Nasiri Saleh Bertil Nlend Rodric Merime Nonki Christina Orieschnig Katerina Papagiannaki Gopal Penny Olga Petrucci Rafael Pimentel Sandra Pool Elena Ridolfi Maria Rusca Nivedita Sairam Adarsh Sankaran Namboothiri Ana Carolina Sarmento Buarque Elisa Savelli Lukas Schoppa Kai Schröter Anna Scolobig Mojtaba Shafiei Anna E. Sikorska-Senoner Magdalena Smigaj Claudia Teutschbein Thomas Thaler Andrijana Todorovic Faranak Tootoonchi Roshanak Tootoonchi Elena Toth Ronald van Nooijen Franciele Maria Vanelli Nicolás Vásquez David W. Walker Marthe Wens David J. Yu Heidar Zarei Changrang Zhou Günter BlöschlSammendrag
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This study describes the development of fusogenic liposomes as a drug delivery system for the hydrophobic antimicrobial peptide micrococcin P1 (MP1). The liposomes were formulated using phospholipids with varying acyl chain lengths, with the goal of improving biofilm eradication. Entrapment of MP1 in liposomes effectively improved its stability in solution, as demonstrated by liquid chromatography-mass spectrometry monitoring over a two-month period. Liposomal entrapment lowered the minimum inhibitory concentration of MP1 against several Staphylococcus aureus strains, including clinical isolates, by 4- to 16-folds. Increasing the phospholipid acyl chain length (16-carbon to 20-carbon) in the liposomal composition, resulted not only in an improved entrapment of MP1, but also higher antibiofilm activity. Confocal laser scanning microscopy imaging revealed that the MP1-loaded liposomal effect was likely due to disruption of the biofilm matrix. At a concentration of 0.25 µg/mL, MP1 loaded in 1,2-diarachidoyl-sn‑glycero-3-phosphocholine (DAPC)-based fusogenic liposomes reduced biofilm cell viability by approximately 55 %, compared to only 15 % with free MP1 equivalents. However, the increased liposomal bilayer hydrophobicity via the longer acyl chains compromised the physical stability of the fusogenic liposomes. While MP1-loaded liposomes based on the shorter 16-carbon acyl chain 1,2-dipalmitoyl-sn‑glycero-3-phosphocholine (DPPC) remained stable for two months, the DAPC liposomes were only stable for two weeks. The physical stability was improved by increasing the concentration of the cationic phospholipid, 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), from 25 mol % to 50 mol % in the liposomal composition. Overall, these findings highlight the potential of liposomal systems for delivering hydrophobic peptides like MP1 to Staphylococcus aureus biofilms, offering promise for improving the treatment of biofilm-associated infections.
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Algal-based wastewater remediation systems (phycoremediation) include phycosphere bacterial communities that influence algal growth, pollutant remediation, and downstream applications of biomass as fertilizers or bio-stimulants. This study investigated the bacterial community dynamics in a novel phycoremediation system using a co-culture of the green algae Stigeoclonium sp. and Oedogonium vaucheri. Bacterial abundance was estimated using flow cytometry (FCM), while community composition was assessed through 16S rRNA gene metabarcoding. Additionally, 28 bacterial strains were isolated from the bioremediation experiment, cultured, genetically characterized for identification and screened for production of the auxin phytohormone indole-3-acetic acid (IAA). Metabarcoding showed that the free-living bacterial community consisted of bacteria from both the wastewater effluent and the algal inocula, while the attached phycosphere community was dominated by bacteria from the algal inocula, indicating the stability of the algae-associated phycosphere. Taxa known to include plant growth-promoting bacteria (PGPB) were abundant, and several strains produced IAA. The bacterial community composition, combined with the potential production of phytohormone by isolated bacteria indicates symbiotic or commensal algae-microbe interactions within the phycosphere bacterial communities. Sterile filtration of wastewater effluent, including only the algal inoculum bacterial communities, reduced algal biomass production and increased bacterial abundance. This study highlights the critical role of microbial interactions in engineered ecosystems and provides insights for optimizing algal-based wastewater treatment technologies.
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Forfattere
Payel Bhattacharjee Mari Talgø Syvertsen Igor A. Yakovlev Marcos Viejo Somoano Mallikarjuna Rao Kovi Torgeir Rhoden Hvidsten Torstein Tengs Carl Gunnar Fossdal Jorunn Elisabeth OlsenSammendrag
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