Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2025
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Ana-Maria Pantazica Alexander Hammel Iuliana Caras Irina Ionescu Catalin Tucureanu Adrian Onu Maria Murace Jihong Liu Clarke Crina Stavaru Norica Branza-Nichita Ralph BockSammendrag
Microalgae represent promising production factories for the light-driven, cost-effective production of recombinant proteins. The red microalga Porphyridium purpureum displays particularly favourable transgene expression properties due to the episomal maintenance of transformation vectors at high copy numbers in the nucleus. In this work, we explored the potential of Porphyridium purpureum to synthesise a candidate vaccine against Hepatitis B virus (HBV). We show high-yield expression of an HBV chimeric surface antigen and efficient assembly of virus-like particles (VLPs) in algal cells. We established a purification protocol for the VLPs and conducted vaccination studies in experimental animals. The results demonstrate that the alga-produced HBV antigen elicits superior humoral and cellular immune responses compared to a commercial HBV vaccine produced in yeast. The antigen triggers virus-neutralising antibodies against different HBV variants, including vaccine-escape mutations that evade the immune response to current vaccines in humans. Our work establishes Porphyridium as a highly promising production platform for vaccines and other proteinaceous biopharmaceuticals.
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Foredrag – Dialogmøte med LDIR for utredning av konsekvenser for avgift på torvuttak
Trond Haraldsen
Forfattere
Trond HaraldsenSammendrag
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Forfattere
Begüm Bilgiç Thea Os Andersen Getachew Birhanu Abera Michal Sposob Lu Feng Svein Jarle HornSammendrag
Syngas biomethanation represents a promising pathway to convert recalcitrant feedstocks into biomethane. However, the hydrogen (H2) content in syngas is often insufficient or fluctuates, which affects the overall performance. This study evaluated the effect of H2 addition on syngas conversion efficiency and microbial community dynamics using two trickle bed reactors (TBRs). One TBR was fed with syngas, while another received syngas supplemented with H2. Both TBRs demonstrated the feasibility of converting CO from syngas to methane, with the H2 supplemented TBR outperforming the syngas-only TBR. The H2 supplemented TBR achieved over 90 % conversion rate at a gas loading rate of 15 NL/Lreactor/d and reached peak methane production at a gas loading rate at 20 NL/Lreactor/d. Microbial community structure analysis revealed a dominance of Methanobacterium, a known thermophilic hydrogenotrophic methanogen. Although H2 addition enhanced performance, a decline in conversion efficiency at higher gas loading rates highlights the need for further optimization.