Publications
NIBIOs employees contribute to several hundred scientific articles and research reports every year. You can browse or search in our collection which contains references and links to these publications as well as other research and dissemination activities. The collection is continously updated with new and historical material.
2024
Authors
Knut ØistadAbstract
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Darius KviklysAbstract
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Authors
Xia Wang Dawei Chen Mengnan Guo Yao Ning Mingze Geng Jing Guo Jiahui Gao Dong Zhao Yupeng Zhang Qianpeng Li Lixiang Li Shiyang Li Yanqing Li Xiaoran Xie Xiuli Zuo Jingxin LiAbstract
Colon cancer is increasing worldwide and is commonly regarded as hormone independent, yet recent reports have implicated sex hormones in its development. Nevertheless, the role of hormones from the hypothalamus–hypophysis axis in colitis-associated colorectal cancer (CAC) remains uncertain. In this study, we observed a significant reduction in the expression of the oxytocin receptor (OXTR) in colon samples from both patient with colitis and patient with CAC. To investigate further, we generated mice with an intestinal-epithelium-cell-specific knockout of OXTR. These mice exhibited markedly increased susceptibility to dextran-sulfate-sodium-induced colitis and dextran sulfate sodium/azoxymethane-induced CAC compared to wild-type mice. Our findings indicate that OXTR depletion impaired the inner mucus of the colon epithelium. Mechanistically, oxytocin was found to regulate Mucin 2 maturation through β1-3-N-acetylglucosaminyltransferase 7 (B3GNT7)-mediated fucosylation. Interestingly, we observed a positive correlation between B3GNT7 expression and OXTR expression in human colitis and CAC colon samples. Moreover, the simultaneous activations of OXTR and fucosylation by l-fucose significantly alleviated tumor burden. Hence, our study unveils oxytocin’s promising potential as an affordable and effective therapeutic intervention for individuals affected by colitis and CAC.
Authors
Erico Kutchartt José Ramón González-Olabarria Núria Aquilué Jordi Garcia-Gonzalo Antoni Trasobares Brigite Botequim Marius Hauglin Palaiologos Palaiologou Vassil Vassilev Adrian Cardil Miguel Ángel Navarrete Christophe Orazio Francesco PirottiAbstract
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Authors
Jorunn BørveAbstract
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The aim of this study was to compare various types of peat-free or peat-reduced growing media on growth and flowering of ‘Purple piruette’ petunia hybrids. In experiment 1, 30 variants of growing media, including commercial peat-based growing media, different peat-reduced and peat-free mixtures based on garden/park waste compost and wood fiber were tested. All the peat-free variants failed in producing normal, healthy plants without chlorosis. A commercial peat-reduced growing medium with peat, garden/park waste-compost and crushed rock material (0-2 mm), base fertilized with chicken manure, and similar growing media mixtures with other types of base fertilizer gave larger plants with more flowers than the peat-based reference. The highest performing mixture with the smallest amount of peat (35% wood fiber, 30% garden park/park waste-compost, 30% peat and 5% sand) gave equal results as the commercial peat-reduced growing medium. In experiment 2, further studies of the effect of peat reduction by incorporation of wood fiber and four compost types were performed. The effect of start fertilizer incorporation to the substrates was also assessed. One of the peat-free variants with compost and wood fiber gave normal plants with rich flowering but didn’t reach the performance of pure peat on plant size. The pH (H2O) of the composts seems to be a key factor for successful substrate mixtures of compost and wood fiber. The composts with highest pH gave small plants and start fertilizer had no effects on the growth. The results show that there is a potential for development of peat-free substrates based on compost and wood fiber presuming that pH (H2O) of the composts is not too high.