Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2023
Forfattere
Hang Su Andre van Eerde Espen Rimstad Ralph Bock Norica Branza-Nichita Igor A. Yakovlev Jihong Liu ClarkeSammendrag
Plants provide not only food and feed, but also herbal medicines and various raw materials for industry. Moreover, plants can be green factories producing high value bioproducts such as biopharmaceuticals and vaccines. Advantages of plant-based production platforms include easy scale-up, cost effectiveness, and high safety as plants are not hosts for human and animal pathogens. Plant cells perform many post-translational modifications that are present in humans and animals and can be essential for biological activity of produced recombinant proteins. Stimulated by progress in plant transformation technologies, substantial efforts have been made in both the public and the private sectors to develop plant-based vaccine production platforms. Recent promising examples include plant-made vaccines against COVID-19 and Ebola. The COVIFENZ® COVID-19 vaccine produced in Nicotiana benthamiana has been approved in Canada, and several plant-made influenza vaccines have undergone clinical trials. In this review, we discuss the status of vaccine production in plants and the state of the art in downstream processing according to good manufacturing practice (GMP). We discuss different production approaches, including stable transgenic plants and transient expression technologies, and review selected applications in the area of human and veterinary vaccines. We also highlight specific challenges associated with viral vaccine production for different target organisms, including lower vertebrates (e.g., farmed fish), and discuss future perspectives for the field.
Forfattere
Sunniva Løwø Simeon Rossmann Marte Persdatter Tangvik Monica Skogen Solveig Haukeland Ulrike Naumann May Bente BrurbergSammendrag
Det er ikke registrert sammendrag
Forfattere
Heidi Udnes Aamot Silje Kvist Simonsen Magne Nordang Skårn Katherine Ann Gredvig Nielsen Birgitte Henriksen Guro BrodalSammendrag
Det er ikke registrert sammendrag
Forfattere
Gry Alfredsen Lone Ross Michael Altgen Igor A. Yakovlev Anne-Cathrine Flyen Mari sand Austigaard Johan Mattsson Nanna Bjerregaard PedersenSammendrag
Det er ikke registrert sammendrag
Forfattere
Gry Alfredsen Lone Ross Michael Altgen Igor A. Yakovlev Anne-Cathrine Flyen Mari sand Austigaard Johan Mattsson Nanna Bjerregaard PedersenSammendrag
Det er ikke registrert sammendrag
Forfattere
Gry Alfredsen Lone Ross Michael Altgen Igor A. Yakovlev Anne-Cathrine Flyen Mari sand Austigaard Johan Mattsson Nanna Bjerregaard PedersenSammendrag
Det er ikke registrert sammendrag
Sammendrag
The European spruce bark beetle Ips typographus and the North American spruce beetle Dendroctonus rufipennis cause high mortality of spruces on their native continents. Both species have been inadvertently transported beyond their native ranges. With similar climates and the presence of congeneric spruce hosts in Europe and North America, there is a risk that one or both bark beetle species become established into the non-native continent. There are many challenges that an introduced population of bark beetles would face, but an important prerequisite for establishment is the presence of suitable host trees. We tested the suitability of non-native versus native hosts by exposing cut bolts of Norway spruce (Picea abies), black spruce (Picea mariana) and white spruce (Picea glauca) to beetle attacks in the field in Norway and Canada. We quantified attack density, brood density and reproductive success of I. typographus and D. rufipennis in the three host species. We found that I. typographus attacked white and black spruce at comparable densities to its native host, Norway spruce, and with similar reproductive success in all three host species. In contrast, D. rufipennis strongly preferred to attack white spruce (a native host) but performed better in the novel Norway spruce host than it did in black spruce, a suboptimal native host. Our results suggest that I. typographus will find abundant and highly suitable hosts in North America, while D. rufipennis in Europe may experience reduced reproductive success in Norway spruce.
Forfattere
Theresa Weigl Ingunn Øvsthus Jorunn Børve Hanne Larsen Carl Gunnar Fossdal Siv Fagertun RembergSammendrag
Det er ikke registrert sammendrag
Forfattere
Theresa Weigl Ingunn Øvsthus Hanne Larsen Carl Gunnar Fossdal Jorunn Børve Siv Fagertun RembergSammendrag
Det er ikke registrert sammendrag
Sammendrag
Det er ikke registrert sammendrag