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Publications

NIBIOs employees contribute to several hundred scientific articles and research reports every year. You can browse or search in our collection which contains references and links to these publications as well as other research and dissemination activities. The collection is continously updated with new and historical material.

2021

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Abstract

This paper presents some of the ethical challenges that current care robots raise in home- and healthcare services for senior adults (≥65 years). The paper is grounded in some of the state-of-the-art projects within the area of care robotics.Further, the paper identifies and discusses several central challenges raised by using robots as part of care services for the elderly people. The paper contributes to the ethical debate on the implications care robots may have for the practical context of healthcare. In addition, the paper summarizes the main lines of the EU legal approach to AI robotic technology, offering a comprehensive picture of the existing regulatory, theoretical and research gaps, compelling the need of an interdisciplinary ethical reflection on care robots. Finally, the discussion is then balanced by some of the opportunities the care robots may provide for the care services.

Abstract

This study documents volume increment and natural mortality in 1379 old boreal forests plots during four consecutive inventory cycles in the Norwegian national forest inventory. The stands age up to 100 years beyond recommended rotation length (close to economical optimal rotation length) and comprise a wide range of site productivity classes in both pine- and spruce-dominated forests. The annual gross volume increment was stable and nearly constant up to 50–100 years beyond economically optimal rotation length. In parallel, there was very low natural mortality (0.22–0.66% of standing volume) with minimal risk of stand collapse. Stands with satisfactory stocking had volume increment equal to or higher than the reference volume increment in managed stands harvested at recommended rotation length, while poorly stocked stands had inferior volume increment. From a climate change mitigation perspective, it seems to be a good strategy to extend the rotation length beyond what is currently recommended, provided that the stands have satisfactory stocking.

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Abstract

Rheumatoid arthritis (RA) is a complex disease with a wide range of underlying susceptibility factors. Recently, dysregulation of microRNAs (miRNAs) in RA have been reported in several immune cell types from blood. However, B cells have not been studied in detail yet. Given the autoimmune nature of RA with the presence of autoantibodies, CD19+ B cells are a key cell type in RA pathogenesis and alterations in CD19+ B cell subpopulations have been observed in patient blood. Therefore, we aimed to reveal the global miRNA repertoire and to analyze miRNA expression profile differences in homogenous RA patient phenotypes in blood-derived CD19+ B cells. Small RNA sequencing was performed on CD19+ B cells of newly diagnosed untreated RA patients (n=10), successfully methotrexate (MTX) treated RA patients in remission (MTX treated RA patients, n=18) and healthy controls (n=9). The majority of miRNAs was detected across all phenotypes. However, significant expression differences between MTX treated RA patients and controls were observed for 27 miRNAs, while no significant differences were seen between the newly diagnosed patients and controls. Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR-223-3p, miR-486-3p and miR-23a-3p. MiRNA target enrichment analysis, using the differentially expressed miRNAs and miRNA-target interactions from miRTarBase as input, revealed enriched target genes known to play important roles in B cell activation, differentiation and B cell receptor signaling, such as STAT3, PRDM1 and PTEN. Interestingly, many of those genes showed a high degree of correlated expression in CD19+ B cells in contrast to other immune cell types. Our results suggest important regulatory functions of miRNAs in blood-derived CD19+ B cells of MTX treated RA patients and motivate for future studies investigating the interactive mechanisms between miRNA and gene targets, as well as the possible predictive power of miRNAs for RA treatment response.

Abstract

Understanding the quality of new raw material sources will be of great importance to ensure the development of a circular bioeconomy. Building up quality understanding of wood waste is an important step in this development. In this paper we probe two main questions, one substantial and one theoretical: What different understandings of wood waste quality exist and what significance do they have for the recycling and re-use of this waste fraction? And, what is the evolution of knowledge and sustainable practices of wood waste qualities a case of? The analysis is based on diverse perspectives and forms of methods and empirical material. Studies of policy documents, regulations, standards, etc. have been reviewed to uncover what kind of measures and concepts that have been important for governing and regulating wood waste handling. Interviews concerning wood and wood waste qualities have been conducted with key informants and people visiting recycling and waste management stations in Oslo and Akershus in Norway. By studying quality conceptions through the social birth, production, life, end-of-life and re-birth of wood products, we analyse socio-cultural conditions for sustainability. Furthermore we show how the evolution of knowledge and sustainable practices of wood waste qualities, in the meeting with standards and regulations, is a case of adaptation work in the evolution of Norwegian bioeconomy.