Publikasjoner
NIBIOs ansatte publiserer flere hundre vitenskapelige artikler og forskningsrapporter hvert år. Her finner du referanser og lenker til publikasjoner og andre forsknings- og formidlingsaktiviteter. Samlingen oppdateres løpende med både nytt og historisk materiale. For mer informasjon om NIBIOs publikasjoner, besøk NIBIOs bibliotek.
2020
Forfattere
Lisa Magdalena Rossbach Deborah H Oughton Erica Maremonti Claire Coutris Dag Anders BredeSammendrag
The current study provides an in vivo analysis of the production of reactive oxygen species (ROS) and oxidative stress in the nematode Caenorhabditis elegans following exposure to EU reference silver nanoparticles NM300K and AgNO3. Induction of antioxidant defenses was measured through the application of a SOD-1 reporter, and the HyPer and GRX biosensor strains to monitor changes in the cellular redox state. Both forms of Ag resulted in an increase in sod-1 expression, elevated H2O2 levels and an imbalance in the cellular GSSG/GSH redox status. Microscopy analysis of the strains revealed that AgNO3 induced ROS-related effects in multiple tissues, including the pharynx, intestinal cells and muscle tissues. In contrast, NM300K resulted in localized ROS production and oxidative stress, specifically in tissues surrounding the intestinal lumen. This indicates that Ag from AgNO3 exposure was readily transported across the whole body, while Ag or ROS from NM300K exposure was predominantly confined within the luminal tissues. Concentrations resulting in an increase in ROS production and changes in GSSG/GSH ratio were in line with the levels associated with observed physiological toxic effects. However, sod-1 was not induced at the lowest Ag concentrations, although reprotoxicity was seen at these levels. While both forms of Ag caused oxidative stress, impaired development, and reprotoxicity, the results suggest different involvement of ROS production to the toxic effects of AgNO3 versus NM300K.
Sammendrag
Mikroplast hoper seg opp i matjord. Ingen vet hvor mye det er av den, og det finnes ikke teknologi som kan stoppe den helt. Forsker Claire Coutris på Nibio har sett på forskning på plast over hele verden. Plasten i havet har fått mye oppmerksomhet, men problemet er stort i matjord, også. Siden 1950-tallet er det produsert 8,3 milliarder tonn plast i verden. Mesteparten av den har havnet enten i naturen eller på fyllinga. Mikroplasten – partikler som er mindre enn fem millimeter store – kommer i jorda blant annet når bonden gjødsler. Når matavfall blir til biogass, så blir det igjen det som kalles «biorest». Den kan brukes som god og næringsrik gjødsel. Anleggene bruker separasjonsteknologi for å ta ut fremmedelementer i matavfallet, som glass, plast og metall. Likevel skjer det at mindre plastfragmenter fra matemballasje og annen feilsortert søppel følger med i bioresten.
Sammendrag
Det er ikke registrert sammendrag
Forfattere
Claire CoutrisSammendrag
Det er ikke registrert sammendrag
Forfattere
Claire CoutrisSammendrag
Det er ikke registrert sammendrag
Forfattere
Anastasia Georgantzopoulou Julia Farkas Kuria Ndungu Claire Coutris Patricia Almeida Carvalho Andy M Booth Ailbhe MackenSammendrag
In this study, the effects of aged Ag and TiO2 nanoparticles (NPs), individually and as a mixture, in wastewater relative to their pristine counterparts on the development of the copepod nauplii (Tisbe battagliai) were investigated. NP behavior in synthetic wastewater and seawater was characterized during aging and exposure. A delayed development and subsequent mortality were observed after 6 days of exposure to aged Ag NPs, with a twofold decrease in EC50 (316 μg/L) compared to pristine NPs (EC50 640 μg/L) despite the similar dissolved Ag concentrations measured for aged and pristine Ag NPs (441 and 378 μg/L, respectively). In coexposures with TiO2 NPs, higher dissolved Ag levels were measured for aged NPs (238.3 μg/L) relative to pristine NPs (98.57 μg/L). Coexposure resulted in a slight decrease (15%) in the Ag NP EC50 (270 μg/L) with a 1.9-fold increase in the Ag NP retained within the organisms after depuration (2.82% retention) compared to Ag NP single exposures as measured with sp-ICP− MS, suggesting that the particles are still bioavailable despite the heteroaggregation observed between Ag, Ti NPs, and wastewater components. This study shows that the presence of TiO2 NPs can affect the stability and toxicity of Ag NPs in complex media that cannot be predicted solely based on ionic, total, or nanoparticulate concentrations, and the need for studying NP interactions in more complex matrices is highlighted.
Sammendrag
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Sammendrag
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Sammendrag
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Forfattere
Eva BrodSammendrag
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